The anopheles gambiae genome an update

Conclusion: This study has used new approaches to improve the physical map and assembly of the A. Abstract Background: The genome of Anopheles gambiae, the major vector of malaria, was sequenced and assembled in Publication types Research Support, N. Substances Euchromatin. Figure 1. Map of the four collection sites in the Gambia and Guinea Bissau. Results We genotyped one marker per centromeric region on each of the three independently assorting chromosomes i. P The Gambia MB 0.

Figure 2. Association between chromosome-X, -2 and -3 centromeric regions The complete association between X-, 2L- and 3L-centromeres observed by White et al.

Discussion Previous studies have shown that in A. DOC Click here for additional data file. Table S1 Numbers N of 3-locus genotypes in the 35 Anopheles gambiae adult females whose 2L and 3L centromere genotypes were determined by direct sequencing. Acknowledgments We thank the entomological teams and the local residents for assistance during mosquito collections in The Gambia and in Guinea Bissau.

Footnotes Competing Interests: The authors have declared that no competing interests exist. References 1. Rundle HD, Nosil P. Ecological speciation. Ecology Letters. Divergent selection and heterogeneous genomic divergence. Mol Ecol. Molecular evidence of incipient speciation within Anopheles gambiae s. Insect Mol Biol. Attempts to molecularly distinguish cryptic taxa in Anopheles gambiae s. On the distribution and genetic differentiation of Anopheles gambiae s.

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DNA analysis of transferred sperm reveals significant levels of gene flow between molecular forms of Anopheles gambiae. Species and populations of the Anopheles gambiae complex in Cameroon with special emphasis on chromosomal and molecular forms of Anopheles gambiae s. Distribution and chromosomal characterization of the Anopheles gambiae complex in Angola. Am J Trop Med Hyg. Dynamics of transmission of Plasmodium falciparum by Anopheles arabiensis and the molecular forms M and S of Anopheles gambiae in Dielmo, Senegal.

Anopheles gambiae complex along The Gambia river, with particular reference to the molecular forms of An. High levels of hybridization between molecular forms of Anopheles gambiae from Guinea Bissau. Evaluating the effect of postmating isolation between molecular forms of Anopheles gambiae Diptera: Culicidae. Genomic islands of speciation in Anopheles gambiae. PLoS Biol. Genetic association of physically unlinked islands of genomic divergence in incipient species of Anopheles gambiae. Widespread divergence between incipient Anopheles gambiae species revealed by whole genome sequences.

Complex gene flow boundaries among sympatric Anopheles vector mosquito populations revealed by genome-wide SNP genotyping. Med Vet Entomol. Short report: A new polymerase chain reaction-restriction fragment length polymorphism method to identify Anopheles arabiensis from An. Insertion polymorphisms of SINE retrotransposons within speciation islands of Anopheles gambiae molecular forms. Identification of single specimens of the Anopheles gambiae complex by the polymerase chain reaction.

Nucleic Acids Res. Raymond M, Rousset F. Genepop Version Journal of Heredity. Arlequin version 3. Evol Bioinform Online. Slatkin M, Excoffier L. Mol Cells , 15 2 , 01 Apr Cited by: 0 articles PMID: Tabachnick WJ. J Med Entomol , 40 5 , 01 Sep Cited by: 28 articles PMID: Cited by: 41 articles PMID: Contact us. Europe PMC requires Javascript to function effectively.

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Louis C ,. Holt RA ,. Birney E ,. Collins FH. Affiliations 1 author 1. Share this article Share with email Share with twitter Share with linkedin Share with facebook. Abstract As a result of an international collaborative effort, the first draft of the Anopheles gambiae genome sequence and its preliminary annotation were published in October Since then, the assembly, annotation and means of accession of the An. This article reviews progress and considers limitations in the current sequence assembly and gene annotation, as well as approaches to address these problems and outstanding issues that users of the data must bear in mind.

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